body{font-family:Times New Roman,Helvetica,sans-serif; font-size:100%;font-weight:normal; margin: 2% 2% 2% 2%;line-height:150%;}

/*
body{font-family:Arial,sans-serif; font-size:95%;font-weight:normal; margin: 2% 2% 2% 2%;line-height:150%;}
*/

/* 
#wrapper{width:100%;}
table{font-size:14px}
th {font-weight:normal}
#btnGB {border:solid 1px;background-color:Khaki;}
*/

.firstpara { margin-left: 0px; text-indent: 0px; text-align: left; margin-bottom: 0pt }
.otherpara { margin-left: 0px; text-indent: 20px; text-align: left; margin-top: 0pt; margin-bottom: 0pt; }
.RSCLink {font-weight: bold;font-size:70%;background-color:#C0C0C0;color:black;text-decoration:none;border-style:solid;border-width:1px; padding:1px;font-family:Arial, Geneva, sans-serif;}
.btnLink{font-size:75%;background-color:#F5F5F5;color:black;text-decoration:none;border-style:solid;border-width:1px; padding:2px;font-family:Arial, Geneva, sans-serif;}
.btnContainer{padding-right:0.5em;}
.rsc-logo{padding:25px 5px 35px 0px;}


.head_wrap{margin:0 auto;}
.right_head{display:inline;float:right;text-align:right;width:50%;}
.left_head{float:left;text-align:left;vertical-align:bottom;padding:0em 0em 1em 0em;width:50%;}
.article_info{border-bottom:thin solid black;clear:both;}
.COILink {font-size:70%;background-color:#FAFAFA;color:black;text-decoration: none;border-style:solid;border-width:1px; padding:2px;font-family:Arial, Geneva, sans-serif;}
.DOILink {font-size:70%;background-color:#FAFAFA;color:black;text-decoration: none;border-style:solid;border-width:1px; padding:2px;font-family:Arial, Geneva, sans-serif;}
.PMedLink {font-size:70%;background-color:#FAFAFA;color:black;text-decoration: none;border-style:solid;border-width:1px; padding:2px;font-family:Arial, Geneva, sans-serif;}
.oa {text-align:left;}

#open-crossmark{border: 0; display:inline;padding: 2.5em 0 1em 0;}
#crossmark-logo{border: 0; display:inline;width: 100px;}

/* DERA-Prospect TC Compounds, AN Biomed, CH Chemical*/
/* This change for non MEDCHEMCOMM articles remove if MD applied to all */
a.simple{text-decoration:none;color:black;}

a.ALL:hover {text-decoration:underline;cursor:pointer;}
a.tab{padding-right:0.5em;}
#btnTC{background-color:#E7E74A;cursor:pointer;font-size:75%;vertical-align:super;color:black;text-decoration:none;border-style:solid;border-width:1px; padding:2px;font-family:Arial, Geneva, sans-serif;}
.TC:hover{background-color:#E7E74A;cursor:pointer;text-decoration:none}
.TC{text-decoration:none;color:black;}
.RTC:hover{background-color:#E7E74A;cursor:pointer;text-decoration:none}
.RTC{text-decoration:none;color:black;}
#btnCH{background:#C6F3F6;cursor:pointer;font-size:75%;vertical-align:super;color:black;text-decoration:none;border-color:black;border-style:solid;border-width:1px;  padding:2px;font-family:Arial, Geneva, sans-serif;}
.CH:hover{background:#C6F3F6;cursor:pointer;text-decoration:none}
.CH{text-decoration:none;color:black;}
#btnAN{background-color:#DEDCD3;cursor:pointer;font-size:75%;vertical-align:super;color:black;text-decoration:none;border-style:solid;border-width:1px; padding:2px;font-family:Arial, Geneva, sans-serif;}
.AN:hover{background-color:#DEDCD3;cursor:pointer;text-decoration:none}
.AN{text-decoration:none;color:black;}
.GB:hover{background-color:Khaki;cursor:pointer;text-decoration:none}
.GB{text-decoration:none;color:black;}



/* Tooltip */
.complink {text-align:center;font-weight:900;margin-bottom:1em;background-color:#0A2C35;color:white;padding:2px;}
.ANlink {text-align:center;font-weight:900;margin-bottom:1em;color:black;background-color:#DEDCD3;text-transform:uppercase;}
.CHlink {text-align:center;font-weight:900;margin-bottom:1em;color:#C6F3F6;background-color:white;text-transform:uppercase;}

#chemnav{padding-top:10px;}
#imgover { position:absolute; visibility:hidden;}

/* Headings */

.title_heading{font-size: 100%;margin-top: 2%; margin-bottom: 2%;font-weight: bold;line-height:120%;font-family:Arial, Geneva, sans-serif;}
.a_heading{font-size: 95%;margin-top: 2%; margin-bottom: 2%;font-weight: bold;font-family:Arial, Geneva, sans-serif;}
.b_heading{font-size: 95%;margin-top: 2%; margin-bottom: 2%;font-weight: bold;font-family:Arial, Geneva, sans-serif;}
.c_heading_indent{font-size: 95%;display:inline-block;text-indent: 20px;margin-right:5px;font-weight: bold;font-family:Arial, Geneva, sans-serif;}
.d_heading_indent{font-size: 95%;display:inline-block;font-style:italic; text-indent:30px; margin-right:5px; font-family:Arial, Geneva, sans-serif;}
.e_heading{font-size: 95%;font-style:italic;font-family:Arial, Geneva, sans-serif;}
.e_heading_indent{font-size: 95%;font-style:italic; text-indent:40px;font-family:Arial, Geneva, sans-serif;}

/* General */

.abstract{font-weight: normal;width:80%}
.header_text{margin-top: 2%;}
.graphic_title{text-align:right;}
.text_indent{text-indent:2%;}
.p{text-align:left;}
.bold{font-weight: bold;}     
.italic{font-style:italic;}
.sup_ref{font-size:80%;}
.header_text{font-size: 100%;}
.small_caps{font-variant: small-caps;}
.tfootnote{vertical-align:text-top;font-style:italic;font-size:70%} 
.sansserif{font-family:Arial;}
.ul{text-decoration:underline;}
.ol{text-decoration:overline;}
.warning{color:red;}
.sup_inf{font-size: 80%;}
.authgrp_book{font-style:italic;}
.authgrp_news{font-weight:bold;margin-top:2%;text-align:right;}
.centered {text-align: center;}
.div.centered table {margin: 0 auto; text-align: left;}
.tblrowbottom{vertical-align:bottom;}
.box_border{border:1px solid black;border-spacing:1em 1em;}
.simple_table{text-align: center; width:100%;}
.hrule{margin: 0px; height: 1px; border: 1px solid black}
.border_black{border-bottom:1px solid black}
.border_bottom_thin{border-bottom:thin solid black}         
.border_top_bottom{border-top:thin solid black;border-bottom:thin solid black}
.centered{text-align: center;}
.leftalign{text-align: left;}
.charmap{border: 0;}

/* TOC */

.contents{list-style-type: none;}

/* images and equations */

.image_title{border-bottom: 1px solid #999999;width:50%;text-align:left;}
td.pushTitleRight{width:25%;}
td.pushTitleLeft{width:25%;text-align:right;}
td.imgHolder{text-align:center;}
td.titleHolder{width:50%;text-align:center;}
td.leftEqn{width:10%;}
td.rightEqn{text-align:right;width:10%;}
td.eqn{text-align:center;width:80%;}
td.eqnText{text-align:center;}
td.biogPlate{width:25%;text-align:center;}
img{max-width:80%;border: 0;}

/* table element styles */

table{font-size:100%;border:0;width:100%;}
.tblrbottom {vertical-align:bottom;}
.tgroup{width:100%;}
.table_caption{padding:1em 0em 0em 0em;border-bottom:thin solid black;}


#orcid-id-logo {
    padding: 0px 1px 0px 2px;
    vertical-align: baseline;
}
/* SPECIFIC CSS FOR THE RICH HTML */
html, body {
    background-color: #F6F6F7;
    -webkit-font-smoothing: antialiased;
    -webkit-text-size-adjust: 100%;
    line-height: 150%;
}

@media only screen and (min-width: 1168px) {
    .pubs-ui .viewport {
        max-width: 1168px;
        padding-left: 24px;
        padding-right: 24px;
        width: 100%;
    }
}

@media only screen and (min-width: 1460px) {
    .pubs-ui .viewport {
        max-width: 1168px;
        padding-left: 32px;
        padding-right: 32px;
        width: 100%;
    }
}

.pubs-ui .rtable__wrapper {
    max-width: 100%;
    overflow: hidden;
    overflow-x: auto;
}

.pubs-ui .rtable__inner {
    min-width: 6200px;
    width: 100%;
}

.pubs-ui .rtable {
    width: auto;
}

@media only print {
    html, body {
        background-color: #FFFFFF !important;
    }

    .pubs-ui #wrapper p,
    .pubs-ui #wrapper span {
        font-size: 16px;
    }
}

.pubs-ui .pushTitleRight,
.pubs-ui .pushTitleLeft {
    width: 0.0001%;
}

.pubs-ui #wrapper img {
    max-width: 100%;
}

    .pubs-ui #wrapper img:not('crossmark-logo') {
        box-sizing: border-box;
        padding: 24px;
    }

.pubs-ui #wrapper p,
.pubs-ui #wrapper span {
    line-height: 1.875em;
}

@media only screen and (min-width: 1168px) {
    .pubs-ui #wrapper p,
    .pubs-ui #wrapper span {
    }
}

.pubs-ui .image_table {
    margin: 32px 0;
}

.pubs-ui #wrapper .biogPlate img {
    box-sizing: border-box;
    min-width: 160px;
    padding: 24px 0 0 0;
}

.pubs-ui td.biogPlate a {
    display: block;
}

.pubs-ui td.biogPlate {
    display: block;
    vertical-align: top;
}

    .pubs-ui td.biogPlate ~ td {
        display: block;
        vertical-align: top;
    }

.pubs-ui #wrapper .abstract {
    box-sizing: border-box;
    width: 100%;
    padding: 24px;
}

    .pubs-ui #wrapper .abstract h2 {
        font-family: 'Gotham', Arial, sans-serif;
        font-size: 24px;
        font-weight: 400;
        margin-bottom: 12px;
        letter-spacing: -0.03em;
    }

.pubs-ui #wrapper h1,
.pubs-ui #wrapper h2,
.pubs-ui #wrapper h3,
.pubs-ui #wrapper h1 > span,
.pubs-ui #wrapper h2 > span,
.pubs-ui #wrapper h3 > span {
    font-family: 'Gotham', Arial, sans-serif;
    line-height: 1.2em;
    letter-spacing: -0.03em;
}

.pubs-ui #wrapper .btnContainer a {
    display: inline-block;
    margin-bottom: 12px;
    xmin-height: 32px;
    word-break: keep-all;
    white-space: nowrap;
}

    .pubs-ui #wrapper .btnContainer a.btn--light {
        background-color: #F6F6F7;
    }

@media only screen and (min-width: 584px) {
    .pubs-ui #wrapper .biogPlate img {
        padding: 24px 24px 0px 24px;
    }

    .pubs-ui td.biogPlate {
        display: table-cell;
        width: 240px;
    }

        .pubs-ui td.biogPlate ~ td {
            display: table-cell;
            width: calc(100% - 240px);
        }
}

.pubs-ui #wrapper {
    word-wrap: break-word;
}

    .pubs-ui #wrapper .oa {
        display: block;
        font-size: 12px;
        line-height: 20px;
        padding: 4px;
        text-align: right;
    }

.pubs-ui .TC, .pubs-ui .TC a {
    text-decoration: none;
    color: #474747;
    padding: 0 4px;
}

.pubs-ui .RTC a {
    text-decoration: none;
    color: #474747;
    padding: 0 4px;
}

.pubs-ui .CH a {
    text-decoration: none;
    color: #474747;
    padding: 0 4px;
}

.pubs-ui .AN a {
    text-decoration: none;
    color: #474747;
    padding: 0 4px;
}

.pubs-ui .GB a {
    text-decoration: none;
    color: #474747;
    padding: 0 4px;
}

.pubs-ui #chemnav a .tab {
    border: 0;
    display: inline-block;
    font-family: 'Source Sans Pro', 'source-sans-pro', Arial, sans-serif;
}

.pubs-ui #btnTC {
    background-color: #BACD00;
    border: 0;
    border-bottom: 1px solid rgba(25,25,25,0.2);
    cursor: pointer;
    text-decoration: none;
    padding: 4px 8px;
    font-family: 'Source Sans Pro', 'source-sans-pro', Arial, sans-serif;
    white-space: nowrap;
}

.pubs-ui #btnAN {
    background-color: #D1CCBD;
    border: 0;
    border-bottom: 1px solid rgba(25,25,25,0.2);
    cursor: pointer;
    text-decoration: none;
    padding: 4px 8px;
    font-family: 'Source Sans Pro', 'source-sans-pro', Arial, sans-serif;
    white-space: nowrap;
}

.pubs-ui #btnCH {
    background-color: #E99814;
    border: 0;
    border-bottom: 1px solid rgba(25,25,25,0.2);
    cursor: pointer;
    text-decoration: none;
    padding: 4px 8px;
    font-family: 'Source Sans Pro', 'source-sans-pro', Arial, sans-serif;
    white-space: nowrap;
}

    .pubs-ui #btnTC:hover,
    .pubs-ui #btnAN:hover,
    .pubs-ui #btnCH:hover {
        background-color: #FFFFFF;
}

/* PUBS-3334 AHTML Restore ‘RETRACTED’ background to entire page */
.ahtml-page .pnl {
  background-color: white;
}

.ahtml-page.retracted .pnl  {
  background-color: transparent;
}

.ahtml-page.retracted {
  background-image: url(../NewImages/retract.png);
}