From the journal:

Chemical Communications

Detection and resolution of sub-millimolar concentration amino acids on a benchtop NMR spectrometer by nh-PHIP hyperpolarization†

Mateusz Urbańczyk, ORCID logo a   Kärolin Kork,b   Kerti Ausmees, ORCID logo b   Tomasz Ratajczyk ORCID logo a  and  Indrek Reile ORCID logo *b  

* Corresponding authors

a Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland

b National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
E-mail: indrek.reile@kbfi.ee

Abstract

Parahydrogen based nh-PHIP hyperpolarization is used to circumvent the sensitivity and resolution limitations of affordable benchtop spectrometers, allowing the detection and resolution of a mixture of dilute amino acids using an 80 MHz instrument.

Graphical abstract: Detection and resolution of sub-millimolar concentration amino acids on a benchtop NMR spectrometer by nh-PHIP hyperpolarization

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Article information

DOI
https://doi.org/10.1039/D5CC02870A
Article type
Communication
Submitted
20 May 2025
Accepted
18 Jul 2025
First published
22 Jul 2025

Chem. Commun., 2025, Advance Article

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Detection and resolution of sub-millimolar concentration amino acids on a benchtop NMR spectrometer by nh-PHIP hyperpolarization

M. Urbańczyk, K. Kork, K. Ausmees, T. Ratajczyk and I. Reile, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02870A

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