From the journal:

Chemical Communications

Chemical proteomics reveals hesperidin and hesperetin as AKR1C1/2 inhibitors with chemosensitization effect†

Lijun Chen,ab   Yuanyuan Zhou,*a   Yiyun Geng, ORCID logo a   Jianjia Liang,b   Hongyue Ma,b   Lu Ran,b   Jingyuan Xu,a   Zhangshuang Deng*b  and  Yiqing Zhou ORCID logo *b  

* Corresponding authors

a School of Biotechnology and Food Engineering, Suzhou University of Technology, Suzhou 215500, China
E-mail: yyzhou8601@126.com

b Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
E-mail: zhyq2012@gmail.com, d.zhangshuang@ctgu.edu.cn

Abstract

The natural flavanone hesperidin and its aglycone hesperetin were identified as human aldo-keto reductase family 1 member C1 (AKR1C1) and AKR1C2 inhibitors via chemoproteomic profiling, which provides mechanistic insight into their chemosensitization effects in cancer therapy.

Graphical abstract: Chemical proteomics reveals hesperidin and hesperetin as AKR1C1/2 inhibitors with chemosensitization effect

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Article information

DOI
https://doi.org/10.1039/D5CC02907D
Article type
Communication
Submitted
25 May 2025
Accepted
17 Jul 2025
First published
19 Jul 2025

Chem. Commun., 2025, Advance Article

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Chemical proteomics reveals hesperidin and hesperetin as AKR1C1/2 inhibitors with chemosensitization effect

L. Chen, Y. Zhou, Y. Geng, J. Liang, H. Ma, L. Ran, J. Xu, Z. Deng and Y. Zhou, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02907D

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