From the journal:

Chemical Communications

Interfacially self-assembled ChOx/HRP proteinosomes for rapid and sensitive cholesterol detection†

Miaomiao Xu, ORCID logo a   Chenxi Shi,a   Jiaqian Li,a   Shenghao Hu,a   Shuqing Gana  and  Lixing Weng ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing, Jiangsu, China
E-mail: lxweng@njupt.edu.cn

Abstract

This study developed a novel cholesterol biosensing system based on interfacial self-assembled ChOx/HRP dual-enzyme proteinosomes, eliminating the need for complex synthesis. The immobilization of ChOx and HRP on the proteinosome surface enhanced enzyme stability, while the confined spatial proximity of the enzymes significantly improved cascade reaction efficiency, enabling rapid and highly sensitive cholesterol detection.

Graphical abstract: Interfacially self-assembled ChOx/HRP proteinosomes for rapid and sensitive cholesterol detection

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Article information

DOI
https://doi.org/10.1039/D5CC02979A
Article type
Communication
Submitted
26 May 2025
Accepted
24 Jul 2025
First published
24 Jul 2025

Chem. Commun., 2025, Advance Article

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Interfacially self-assembled ChOx/HRP proteinosomes for rapid and sensitive cholesterol detection

M. Xu, C. Shi, J. Li, S. Hu, S. Gan and L. Weng, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02979A

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