Membranes with right recipe can potentially give exceptionally high product water flux with high rejection, recovery ratio, prolonged life with anti-fouling capabilities, low operating costs, and low operating expenses. In this regard, an innovative AlFe2O4 functionalized bentonite (AlFe2O4@BT) was prepared to be used as performance boosting agent in Polyethersulfone (PES)-based mixed matrix loose nanofiltration membrane (LNM). Herein, the fabrication PES-based mixed achieved by blending different wt.% of AlFe2O4@BT material through phase inversion technology. The effects of AlFe2O4@BT on the structure and functionality of the new material AlFe2O4 @BT-PES NLMs were thoroughly examined by scanning electron microscopy, contact angle, antifouling measurements and so on. The Separation efficiency of AlFe2O4@BT-PES based LNM was recorded up to 80%, 85% and 95% of Crystal violet (CV), Congo Red (CR), and humic acid, respectively with exceptional high product flux efficiencies and anti-fouling properties to commercial polyamide membranes. The new LMMs operate at relatively low operating pressure (1-4 bar) which makes them sustainable separation process with lower flux decline ratio and high recovery ratio making it superior membrane material combination.