From the journal:

Natural Product Reports

The development of Burkholderia bacteria as heterologous hosts†

Stephanie C. Heard ORCID logo a  and  Alessandra S. Eustáquio ORCID logo *a  

* Corresponding authors

a Department of Pharmaceutical Sciences and Center for Biomolecular Sciences, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA
E-mail: ase@uic.edu

Abstract

Covering up to 2024

Drug resistance is a serious and growing problem, and new small molecules are needed for a wide variety of clinical and agricultural applications. Natural products, encoded by biosynthetic gene clusters, have consistently been a source of chemical diversity for finely tuned interactions with a range of molecular targets of interest. However, many gene clusters are not transcriptionally active, making heterologous expression in a different host strain a useful tool to access bioactive small molecules. Burkholderia spp. bacteria hold promise as heterologous hosts because of their intrinsic natural product capabilities. In this review, we summarize natural products successfully isolated from Burkholderia spp. heterologous hosts up until 2024. We then compare the hosts that have been tested and discuss ongoing development efforts to improve access to new natural products in titers sufficient for drug development and industrial applications.

Graphical abstract: The development of Burkholderia bacteria as heterologous hosts

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Article information

DOI
https://doi.org/10.1039/D5NP00024F
Article type
Review Article
Submitted
07 Apr 2025
First published
28 Jul 2025
This article is Open Access
Creative Commons BY-NC license

Nat. Prod. Rep., 2025, Advance Article

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The development of Burkholderia bacteria as heterologous hosts

S. C. Heard and A. S. Eustáquio, Nat. Prod. Rep., 2025, Advance Article , DOI: 10.1039/D5NP00024F

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