From the journal:

Organic & Biomolecular Chemistry

A carrier-free nano-photosensitizer for red light-activated NO release and combination therapy

Chaonan Li,a   Huixuan Qi, ORCID logo b   Jinjun Jia,c   Qingxia Lin*c  and  Wenhai Lin ORCID logo *b  

* Corresponding authors

a School of Environment and Biological Engineering, Wuhan Technology and Business University, Hongshan District, Wuhan 430065, China

b Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China
E-mail: whlin@suda.edu.cn

c Department of Psychiatry, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou 325003, China
E-mail: 380364613@qq.com

Abstract

In this work, multifunctional nanoparticles (A-PIB NPs) constructed by a nitric oxide (NO) donor, L-arginine, and a boron dipyrromethene derivative were used for red light-responsive and spatiotemporally-controllable NO release. A-PIB NPs could produce singlet oxygen and NO under 630 nm light irradiation, achieving controlled release of NO and being used for combination therapy of tumors.

Graphical abstract: A carrier-free nano-photosensitizer for red light-activated NO release and combination therapy

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Article information

DOI
https://doi.org/10.1039/D5OB00959F
Article type
Communication
Submitted
10 Jun 2025
Accepted
12 Aug 2025
First published
12 Aug 2025

Org. Biomol. Chem., 2025, Advance Article

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A carrier-free nano-photosensitizer for red light-activated NO release and combination therapy

C. Li, H. Qi, J. Jia, Q. Lin and W. Lin, Org. Biomol. Chem., 2025, Advance Article , DOI: 10.1039/D5OB00959F

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