From the journal:

Organic & Biomolecular Chemistry

Divergent Synthesis of 3-Formylpyrazolo[1,5-a]pyrimidines and Methylene-Bridged Bis(pyrazolo[1,5-a]pyrimidines) using DMSO as a Single Carbon Synthon

Papiya Sikdar,   Sourav Das,   Sheetal Saini,   Sanghapal D. Sawant  and  Avik Kumar Bagdi  

Abstract

A divergent approach has been explored for synthesizing 3-formylpyrazolo[1,5-a]pyrimidines and methylene-bridged bis(pyrazolo[1,5-a]pyrimidines) using DMSO as C1 synthon. A library of 3-formylpyrazolo[1,5-a]pyrimidines and methylene-bridged bis(pyrazolo[1,5-a]pyrimidines) have been synthesized using CuOAc and AcOH respectively. The reaction progressed through a radical pathway. The usefulness of 3-formylpyrazolo[1,5-a]pyrimidines in synthesizing Zaleplon derivative has been demonstrated.

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Article information

DOI
https://doi.org/10.1039/D5OB01042J
Article type
Communication
Submitted
25 Jun 2025
Accepted
28 Jul 2025
First published
29 Jul 2025

Org. Biomol. Chem., 2025, Accepted Manuscript

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Divergent Synthesis of 3-Formylpyrazolo[1,5-a]pyrimidines and Methylene-Bridged Bis(pyrazolo[1,5-a]pyrimidines) using DMSO as a Single Carbon Synthon

P. Sikdar, S. Das, S. Saini, S. D. Sawant and A. K. Bagdi, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D5OB01042J

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