Oxidative Functionalization of Cyclopentane-1,3 Diones: Cell Imaging Studies of Diphenothiazine Derivatives.
Abstract
This article presents a metal free expedient approach for simultaneous incorporation of heteroatoms and unsaturation in the cyclopentane-1,3-dione via aerial oxidation. We have introduced three distinct methodologies viz. secondary and tertiary amination, dimethylation and diphenothiazine construction (C(sp²)-S bonds) in moderate to high yield. The method is highly scalable and compatible with a wide range of substrates. Synthesized fluorescent diphenothiazine derivatives are studied for their photophysical properties and revealed impressive fluorescence. Notably, these compounds are non-cytotoxic, and promising candidates for cell imaging studies on breast cancer (MCF-7) cell lines.
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