Design and Preparation of Novel Imidazolinone Backbone Chiral N, P Ligands and Highly Effective Performances in Enantioselective Allylations
Abstract
Based on a patented new concept of general chiral catalysis, a series of new chiral ligands integrated with both a Macmillan imidazolinone organocatalyst and a chiral N, P-ligand scaffolds have been designed and concisely prepared from commercially available chiral α-amino acids and 2-diphenylphosphino-benzaldehyde. Those chiral ligands have shown good to excellent enantioselectivities (up to 97% ee) with satisfactory yields (up to 95%) in enantioselective Pd-catalyzed allylations with 1,3-dicarbonyls and amines.
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